Assisted Reproduction TechniquesDiagnostic tests

Sperm DNA Fragmentation Test

What is the Sperm DNA Fragmentation test?

It is an exam that measures the integrity of the genetic material of a sperm sample by analyzing the break or damage in the DNA chains of the sperm.

Why is this information important?

Sperm DNA Fragmentation is inversely related to its ability to fertilize, and therefore, the higher the DNA fragmentation of a sperm sample, the smaller its fertilization capacity.

Studies show that approximately 1 out of 4 infertile patients have high levels of fragmentation, whereas the prevalence amongst those patients with normal spermiograms is of approximately 1 out of 10. Therefore, sperm DNA fragmentation should be considered a complementary and independent parameter to traditional spermiograms and survival tests, offering specialists additional and valuable information when it comes to suggesting a treatment.

When can the fragmentation be considered to be anomalous?

It is normally established that above an approximate threshold value of 30 % of DNA Fragmentation the fertilization capacity is seriously committed.

In which cases is it indicated to do the Sperm DNA Fragmentation Test?

It is indicated in the following cases:

  • Low fertilization rate, low quality embryos, repeated implantation failure, repeated miscarriages.
  • Varicocele.
  • Genitourinary infections
  • Patients above 45 years of age.
  • Smokers and people exposed to toxic atmospheres.
  • Exposure to high temperatures (fever)

Do you wish to fix an appointment?

You can fix an appointment to do the Sperm DNA Fragmentation Test:

  • Calling +34 91 788 80 70
  • Or filling in the form you can find in this page

sperm dna

How is the sperm sample obtained?

In order to guarantee the maximum reliability of the spermogram diagnosis, the sperm sample shall be obtained following these indications:

  • Keep 24 hours of sexual abstinence (unless otherwise specified for low sperm quality samples).
  • Collect the sperm sample in a sterile container, we will give you one at Ginefiv, nevertheless you can buy these containers in a pharmacy.
  • Masturbation is the standard method for the sperm sample collection, as neither the interruptus coitus, nor the use of commercial condoms is accepted.
  • The collection of the sperm sample must be performed under hygienic conditions (you will need to wash your hands previously).
  • Be sure that the whole sample is inside the sterile container, because in case most of it falls out of the container, the sample will not be valid. Don’t worry if just a little part of the sample falls out.
  • In the event, you obtain the sample at home:
    • Once you have obtained the sample, make sure you have closed the container properly and that the sample doesn’t get too cold (the sample has to be kept at a temperature between 20ºC and 30ºC, avoiding abrupt temperature changes. That’s why we recommend carrying the sample in an interior pocket).
    • The maximum period of time between the sperm sample collection and its delivery at the laboratory should be of one hour.
  • If you have a temperature (fever) between 7 to 10 days before the sperm sample collection or if you are taking antibiotics, you should contact the laboratory to postpone your appointment.
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